• Supports Estrogen Balance
• Supports Proper Estrogen Metabolism for Women and Men
• Improves Estrogen Detoxification Pathways
• Provides Cellular Antioxidant Support for DNA Stability

Estrogen collectively refers to the female hormones estradiol, estrone and estriol. Hormones have important functions in every area of the body. They are chemical messengers that interact with cells all over the body (especially tissues that are more sensitive to them, including breast and prostate tissues). The most important message they deliver is to grow, divide, and multiply. For this reason, hormones are critically important in human development and tissue repair. Supporting proper estrogen synthesis, metabolism and detoxification is essential for proper hormonal balance. Depending on how estrogen is metabolized it can result in different metabolites, each with individual biological activity.

By keeping hormones in balance and ensuring the body is able to process hormones properly, cruciferous vegetable metabolites work together to reduce hormone overload and maintain cellular health. Current data on metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) suggests that these vegetable metabolites have strong potential for supporting breast, cervical, uterine and prostate health. I3C is a naturally occurring compound derived from cruciferous vegetables such as broccoli, Brussels sprouts and cabbage.

Together, I3C and DIM promote the creation of the more favorable and protective 2-hydroxyestrone (2-OHE) metabolite versus production of 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alphaOHE) metabolites, which can overstimulate cells and create free radicals that cause DNA damage. The influence of I3C and DIM on estrogen metabolism creates a more desirable ratio of 2-OHE to 16-alpha-OHE. This assessment of 2:16 alpha- OHE ratio has been used to evaluate breast health. With this in mind, Estroflex includes targeted doses of both I3C and DIM in one capsule a day dosing to make daily balancing of hormones easy and convenient.

Estroflex is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites I3C and DIM to support proper estrogen metabolism. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites that work together to support estrogen balance, breast and prostate health.

I3C
Indole-3-carbinol (I3C) is a naturally occurring compound found in numerous cruciferous vegetables, such as broccoli, cauliflower, kale and cabbage. Following ingestion of I3C, the body converts it to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C has also been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors. A study published in the Journal of Nutrition unveiled evidence that I3C supports healthy cellular function related to estrogen metabolism.

DIM
Diindolylmethane (DIM) is a phytonutrient and plant indole also found in cruciferous vegetables with potential for enhancing proliferation of healthy cells and cellular activities. As a dimer (formed chemical structure of two substances) of indole-3-carbinol, DIM promotes beneficial estrogen metabolism in both sexes supporting the formation of healthy estrogen metabolites and enhances the potential for greater antioxidant activity.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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